IntroductionIn recent years, there has been something of an explosion of news stories about various college and university campuses across North America experiencing heightened levels of political advocacy and political unrest. Visible examples include the “canceling” of invited speakers who have been deemed offensive by select student groups1 or petitions calling for the removal of instructors who have been accused of using harmful language.2 While these examples shed light on some of the more intense political debates circulating in higher educational (...) institutions, they are also newsworthy stories precisely because they suggest strong divisiveness in worldviews in action—the contradiction between different…. (shrink)

BackgroundBiobanks are considered to be key infrastructures for research development and have generated a lot of debate about their ethical, legal and social implications. While the focus has been on human genomic research, rapid advances in human microbiome research further complicate the debate.DiscussionWe draw on two cystic fibrosis biobanks in Toronto, Canada, to illustrate our points. The biobanks have been established to facilitate sample and data sharing for research into the link between disease progression and microbial dynamics in the lungs (...) of pediatric and adult patients. We begin by providing an overview of some of the ELSI associated with human microbiome research, particularly on the implications for the broader society. We then discuss ethical considerations regarding the identifiability of samples biobanked for human microbiome research, and examine the issue of return of results and incidental findings. We argue that, for the purposes of research ethics oversight, human microbiome research samples should be treated with the same privacy considerations as human tissues samples. We also suggest that returning individual microbiome-related findings could provide a powerful clinical tool for care management, but highlight the need for a more grounded understanding of contextual factors that may be unique to human microbiome research.ConclusionsWe revisit the ELSI of biobanking and consider the impact that human microbiome research might have. Our discussion focuses on identifiability of human microbiome research samples, and return of research results and incidental findings for clinical management. (shrink)

In an adaptive clinical trial , key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself. In addition to having distinguishing scientific features, adaptive trials also may involve ethical considerations that differ from more traditional randomized trials. Better understanding of clinical trial experts’ views about the ethical aspects of adaptive designs could assist those planning ACTs. Our aim was to elucidate the opinions of clinical (...) trial experts regarding their beliefs about ethical aspects of ACTs. (shrink)

This volume contains thirteen papers that were presented at the 2017 Annual Meeting of the Canadian Society for History and Philosophy of Mathematics/Société canadienne d’histoire et de philosophie des mathématiques, which was held at Ryerson University in Toronto. It showcases rigorously reviewed modern scholarship on an interesting variety of topics in the history and philosophy of mathematics from Ancient Greece to the twentieth century. A series of chapters all set in the eighteenth century consider topics such as John Marsh’s techniques (...) for the computation of decimal fractions, Euler’s efforts to compute the surface area of scalene cones, a little-known work by John Playfair on the practical aspects of mathematics, and Monge’s use of descriptive geometry. After a brief stop in the nineteenth century to consider the culture of research mathematics in 1860s Prussia, the book moves into the twentieth century with an examination of the historical context within which the Axiom of Choice was developed and a paper discussing Anatoly Vlasov’s adaptation of the Boltzmann equation to ionized gases. The remaining chapters deal with the philosophy of twentieth-century mathematics through topics such as an historically informed discussion of finitism and its limits; a reexamination of Mary Leng’s defenses of mathematical fictionalism through an alternative, anti-realist approach to mathematics; and a look at the reasons that mathematicians select specific problems to pursue. Written by leading scholars in the field, these papers are accessible to not only mathematicians and students of the history and philosophy of mathematics, but also anyone with a general interest in mathematics. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Le but de cet article n'est pas de fournir une quelconque interprétation de la pensée de Deleuze ou de fournir des clés de lectures pour comprendre l'anti Oedipe. Plus modestement je tente de fournir un angle d'approche de cet ouvrage. Mon point de départ est le suivant : bien que Deleuze ait rédigé un ouvrage désormais classique sur Hume, ce dernier n'est que rarement cité parmi les sources de l'anti Oedipe. De là, j'ai esquissé quelques rapprochements afin de permettre d'éclairer (...) l'approche deleuzienne de la maladie mentale. (shrink)

This pamphlet contains essays by Will Herberg, C. Herman Pritchett, David Fellman, Valerie Earle and Sidney Hook on the principle of academic freedom, its implications, and its recognition by the courts. Will Herberg in the opening essay argues that the greatest threat to academic freedom is the politicization of the university, the pressure to convert the university into an agency of social and political action. Unless the university is thoroughly depoliticized and rededicated exclusively to the cause of learning and (...) scholarship, warns Herberg, it will be destroyed. C. H. Pritchett provides a useful summary of nearly all the Supreme Court's decisions bearing in some way on the academic freedom of teachers. Sidney Hook maintains that the Supreme Court has failed to make certain basic distinctions in its opinions, i.e., between the obligations of public employees and employees in private institutions; between those in professions of public trust and those who are not; and between membership in highly disciplined organizations with purposes antithetical to democratic values and membership in others which are broad in purpose and loosely bound together. From an analysis of the opinions of the Supreme Court and the nature and defense of academic freedom, Hook concludes that the court is a very uncertain protector and guide. In matters of professional ethics, it is the faculties themselves which must uphold and enforce standards of professional integrity. Their failure to do so has led to unnecessary and unwise legislative intervention. Recent events on many college and university campuses, and in particular the increasing resort to civil courts to adjudicate what are basically professional disputes, have emphasized the need for the type of discussion contained in this brief volume.--J. P. D. (shrink)

Dans son Traité 29, « Sur la vision », Plotin aborde à ce propos une difficulté consistant à savoir quelle part y joue le « milieu » séparant l’objet senti de l’organe. Cette question occupe les quatre premiers chapitres du traité : afin d’y préciser le rôle du milieu dans la perception visuelle, Plotin en admet provi­soirement la nécessité, dressant au premier chapitre la liste des possibilités théo­riques envisageables à partir de cette hypothèse de travail. Afin de mieux voir les (...) étapes et les enjeux de cette argumentation dense, elliptique et à peine effleurée par les études sur la question, je l’analyse ici à la lumière de textes antérieurs por­tant sur les modalités de la sensation comme telle et sur le problème, plus géné­ral, de la transmission d’une affection à travers un milieu donné. Ces questions, abordées avant Plotin dans des cadres divers et à partir de problématiques va­riant d’un auteur à l’autre (Platon, Aristote et ses successeurs dans le Lycée, Chrysippe de Soles, Plutarque de Chéronée, Pline l’Ancien, Galien de Pergame), ont été retravaillées par Alexandre d’Aphrodise à propos d’un thème précis, pour donner lieu à un modèle original de transmission dont j’aimerais montrer qu’il est d’un apport décisif dans le Traité 29, puisqu’il donne à Plotin l’instru­ment indispensable pour, en l’approfondissant afin de mieux le dépasser, élabo­rer par là sa propre théorie de la vision, solidaire d’un processus de désaffection du milieu perceptif amorcé avant lui. (shrink)

Résumé — Cet article étudie la manière dont Alexandre analyse le monde sensible, en ses structures constitutives et quant aux principes tenus pour être à l’origine ses opérations fondamentales que sont l’altération et le mélange. En premier lieu, il s’agit de voir quels sont les critères pour qu’un étant soit un « corps ». Ensuite, je montre les facteurs mobilisés par Alexandre pour expliquer les caractéristiques de ces corps, leur activité et leur passivité réciproques. Prenant pour point de départ la (...) définition du corps prêtée dans le De anima aux stoïciens comme matière ou composé matériel, j’essaie de dégager, pour le projet d’Alexandre lui-même, le sens de cette étrange reconstruction doxographique. Celui-ci tiendrait à l’orientation résolument « anti-matérialiste » et « anti-réductionniste » de son analyse du sensible : pour lui, ni la constitution ni l’opération des corps ne peuvent être ramenées à leurs conditions nécessaires que sont, respectivement, la matière et le contact physique. À l’exact opposé de la physique stoïcienne, l’aristotélicien développe ainsi sa théorie du sensible en référence aux principes intelligibles et incorporels donnant les véritables fondements à la cohérence du monde corporel, entendue au double sens de la polarité et de la sélectivité réglant les relations entre corps. Pour finir, j’étudie un problème particulier de cosmologie où Alexandre met en application ce programme. Je montre alors l’originalité d’un « naturalisme » qui, de fait, s’est avéré stimulant pour les néoplatoniciens dès Plotin autant qu’ensuite pour les Médiévaux en quête d’une philosophie satisfaisant aux exigences implicitement posées à l’enquête rationnelle par les religions révélées. Et ce serait, en somme, parce que les corps d’Alexandre sont déjà plus que des corps et parce que la physis aristotélicienne devient avec lui plus qu’une pure « nature », que sa physique a pu devenir la référence obligée des penseurs ultérieurs, à qui elle a fourni le cadre de ce qu’on pourrait appeler une approche méta-physique du monde sensible.Corps, matière et contact.— This paper addresses Alexander’s theory of the sensible world, and of the most important sorts of change within it, such as alteration and blending. First, I overview the minimal requirements for an item to be considered a « body » according to Alexander. Then, I determine which factors explain the physical characteristics of the bodies and their mutual interactions . I also examine why Alexander does not find the Stoic account of material bodies to be satisfactory and, I consider Alexander’s strange construal of the Stoic body as a « stuff » composed either of matter, or of matter and qualities. The solution to these questions lies in the « anti-materialist » and « anti-reductionist » orientation of Alexander’s physics : according to him, neither the constitution nor operation of bodies can be reduced to their minimal and necessary conditions . Thus, his position is the exact opposite of the Stoic view : the essence of bodies and their changes can only be understood by reference to the incorporeal and intelligible principles that ultimately form the very factors responsible for the specific « coherence » of the sensible world . Finally, I will examine a specific problem Alexander solves by emphasizing the non-corporeal causes of the natural world. And I will show that his position leads him to a special type of « naturalism », which was particularly exciting for the Neoplatonists and, later, highly consonant with the medieval approaches to accounting for the causes of sensible things. Because bodies are, for Alexander, more than mere bodies, his physics becomes not only the common point of reference for Plotinus and his followers in Late Antiquity and Middle Ages, but also an important point of departure for what we might call a metaphysical approach to the sensible world. (shrink)

Cet article traite de la question de la relation entre la vérité, la liberté et l’identité dans la pensée de Michel Foucault. En considérant la cri-tique de Foucault par Charles Taylor, dans son article «Foucault on Freedom and Truth», j'analyse les implications de l’hypothèse répres-sive sur la sexualité et la prétendue impossibilité d'une libération par la vérité. Le refus par Foucault de considérer l’identité homosexuelle comme une identité fixe relevant d’une connaissance de soi nous conduit à son projet d’existence esthétique. (...) Cette vie créatrice, comme nous le verrons dans ses cours Le Gouvernement de soi et des autres, implique un certain rapport à soi qui nécessite néanmoins un rapport à l’autre. Au sein de ce rapport, ainsi que dans le vouloir-dire-vrai de la parrêsia, on trouve des conceptions de vérité et de liberté qui échappe-raient à la critique taylorienne et qui s'ouvrent sur d'autres possibilités de pratiques de la liberté. (shrink)

Cet article traite de la question de la relation entre la vérité, la liberté et l’identité dans la pensée de Michel Foucault. En considérant la cri-tique de Foucault par Charles Taylor, dans son article «Foucault on Freedom and Truth», j'analyse les implications de l’hypothèse répres-sive sur la sexualité et la prétendue impossibilité d'une libération par la vérité. Le refus par Foucault de considérer l’identité homosexuelle comme une identité fixe relevant d’une connaissance de soi nous conduit à son projet d’existence esthétique. (...) Cette vie créatrice, comme nous le verrons dans ses cours Le Gouvernement de soi et des autres, implique un certain rapport à soi qui nécessite néanmoins un rapport à l’autre. Au sein de ce rapport, ainsi que dans le vouloir-dire-vrai de la parrêsia, on trouve des conceptions de vérité et de liberté qui échappe-raient à la critique taylorienne et qui s'ouvrent sur d'autres possibilités de pratiques de la liberté. (shrink)

Cet article traite de la question de la relation entre la vérité, la liberté et l’identité dans la pensée de Michel Foucault. En considérant la cri-tique de Foucault par Charles Taylor, dans son article «Foucault on Freedom and Truth», j'analyse les implications de l’hypothèse répres-sive sur la sexualité et la prétendue impossibilité d'une libération par la vérité. Le refus par Foucault de considérer l’identité homosexuelle comme une identité fixe relevant d’une connaissance de soi nous conduit à son projet d’existence esthétique. (...) Cette vie créatrice, comme nous le verrons dans ses cours Le Gouvernement de soi et des autres, implique un certain rapport à soi qui nécessite néanmoins un rapport à l’autre. Au sein de ce rapport, ainsi que dans le vouloir-dire-vrai de la parrêsia, on trouve des conceptions de vérité et de liberté qui échappe-raient à la critique taylorienne et qui s'ouvrent sur d'autres possibilités de pratiques de la liberté. (shrink)

This article argues that James Mill's immersion in Presbyterianism inspired an aversion to hierarchical government and a bias in favour of the Church of Scotland. These views are discernible in Bentham's Church-of-Englandism. Bentham argued for disestablishment on principle but, praising the Scottish Church as a , omitted the Kirk from his church reform manifesto. His position on disestablishment, however, and his endorsement of Presbyterianism were aligned with a voluntaryist strain of Presbyterian ecclesiological theory; Presbyterian dissenters and Benthamite Radicals began to (...) protest against the Kirk's established status. Underpinned significantly by Presbyterian tradition and laced with Benthamic influence, a radical voluntary campaign emerged in Scotland which sought to dismantle the old order and usher in a new era of political democracy and religious voluntaryism. Radicalism in Scotland was not solely characterized by the which J. C. D. Clark believes defined Benthamite ideology; Benthamism, it transpires, was not straightforwardly secularist. (shrink)

«... M. Teste avait peut-être quarante ans. Sa parole était extraordinairement rapide, et sa voix sourde. Tout s'effaçait en lui, les yeux, les mains. Il avait pourtant les épaules militaires, et le pas d'une régularité qui étonnait. Quand il parlait, il ne levait jamais un bras ni un doigt: il avait tué la marionnette. Il ne souriait pas, ne disait ni bonjour ni bonsoir; il semblait ne pas entendre le « Comment allez-vous? » Sa mémoire me donna beaucoup à penser. (...) Les traits par lesquels j'en pouvais juger, me firent imaginer une gymnastique intellectuelle sans exemple. Ce n'était pas chez lui une faculté excessive, - c'était une faculté éduquée ou transformée. Voici ses propres paroles: « Il y a vingt ans que je n'ai plus de livres. J'ai brûlé mes papiers aussi. Je rature le vif... Je retiens ce que je veux. Mais le difficile n'est pas là. Il est de retenir ce dont je voudrai demain!... J'ai cherché un crible machinal... »...». (shrink)

(2002). Philosophy of Science 72 (January), 198-208.

Every living science, especially in its early stages, is compelled to devise fresh terms, either by coining new words or by giving new meanings to old ones. Unless and until these fresh terms become absorbed in the vocabulary of everyday speech, their unfamiliarity makes them a target for the shafts of the humourist. There can be no doubt that in the late fifth century B.C. literary criticism was still a new science. We can trace its beginnings in the treatises of (...) the Sophists, many titles of which have been handed down to us. Strepsiades' lesson in metric, though of itself amusing enough, would certainly gain in topical appropriateness if enacted at a time when such investigations were not only much in the air, but were still novel. And the whole ‘Agon’ of the Frogs, the character of which is forecasted in lines 796–802, depicts in the strongest colours the contrasted views of technician and inspirationist. We should therefore naturally expect a play of such a kind, written at such a time, to be full of technical jargon, barely understood by the ‘man in the street,’ and forming the object of his half-contemptuous amusement. That is, I believe, exactly what we do find, to an extent insufficiently recognized. Professor Radermacher, in his recent edition of the Frogs, has rendered valuable service by pointing out the frequent occurrence in that play of technical terms which meet us later in Dionysius of Halicarnassus and other critics. But I believe that technical language lurks unsuspected in many other passages, though the precise meaning may often be beyond recovery. (shrink)

nature of personality and the structure of personality are distinguished, and the thesis that mainstream personality theories in psychology debate structure but not nature is illustrated with definitions. Mainstream theories assume that person ality is an inner determinant of behavior, but according to views in psychiatry, phenomenology and radical behaviorism the nature of personality is transactional. The theory of reinforcement schedules proposes general mechanisms of transac tions, and phenomenology gives particular transactions meaning. Interactionism, which locates personality in the person and (...) the situation, contributes measurement to transactionalism but its paradigmatic status is ambiguous because it implies an internal storage system for behavior. (shrink)

In “Forced to be Free”, Neil Levy surveys the raft of documented decision-making biases that humans are heir to, and advances several bold proposals designed to enhance the patient's judgment. Gratefully, Levy is moved by the psychological research on judgment and decision-making that documents people's inaccuracy when identifying courses of action will best promote their subjective well-being. But Levy is quick to favour the patient's present preferences, to ensure they get “final say” about their treatment. I urge the opposite inclination, (...) raising doubts about whether the patient's “present preferences” are the best expression of their “final say”. When there is adequate evidence that people, by their own lights, overemphasize their present preferences about the future, we should carefully depreciate those preferences, in effect biasing them to make the right decision by their own lights. (shrink)

Professor Linsay has called my attention to the need for an examination of these compounds, with a view to ascertaining whether they are ever used in the Singular by Latin writers, or always in the Plural. From a scholium, probably by Donatus, on Aen. X. 173: insula inexhaustis Chalybum generosa metallis, has come a gloss which appears in the Ansileubus Glossary in two forms: FR 205 Frofra : insula Tirreno mari in quo ferrifodina exercentur, RU 77 Rufa: insula Tirreni maris (...) in qua ferrifodina exercetur. (shrink)